Conducts fundamental and applied research in science and engineering using mass spectrometry, nuclear magnetic resonance (NMR), X-ray crystallography, as well as electron and light microscopy.
A BioAnalytical Core Facility in the Faculty of Science, YSciCore supports a variety of research projects in the areas of science, health and engineering with a focus on life and materials sciences. YSciCore is composed of 3 distinct suites and includes infrastructure for Mass and Nuclear Magnetic Resonance (NMR) spectrometry, X-ray crystallography, biomolecular analysis as well as electron and light microscopy. The core facility is managed and operated by expert full-time staff that handle the day-to-day operation and training of highly qualified personnel (HQP) to use the infrastructure. The core facility is open to internal and external users.
- Mass spectrometry
- Nuclear Magnetic Resonance (NMR) spectrometry
- Light microscopy
- Electron microscopy
- X-ray crystallography
- Chemical industries
- Life sciences, pharmaceuticals and medical equipment
Specialized labs and equipment
| Equipment | Function |
|---|---|
| Bruker 700 MHz Nuclear Magnetic Resonance (NMR) Spectrometer | Data acquisition at room temperature (RT) or with cryo-probe. |
| Zeiss Spinning Disk Confocal Microscope | Live cell imaging. |
| Bruker timsTOF Pro 2 Mass Spectrometer | Trapped Ion Mobility Spectrometry (TIMS) Time-of-Flight (TOF) mass spectrometry. |
| Sciex ZenoTOF 7600 Mass Spectrometer | Time-of-Flight mass spectrometry. |
| Sartorius Octet R4 Protein Analysis System | Real-time, label-free interaction analysis that provides binding kinetics and affinity data using small sample volumes. |
| Applied Biosystems QuantStudio 6 Pro RealTime PCR system | Real-time polymerase chain reaction (PCR) permits the monitoring and quantification of DNA through amplification of specific target DNA sequences. |
| BioTek Synergy H4 Hybrid Microplate Reader | Captures absorbance, chemiluminescence and fluorescence data. |
| Rigaku MicroMax-007 HF X-Ray Diffractometer (XRD) | Collects X-ray diffraction data of protein crystals at 100 K. |
| Zeiss LSM 700 Confocal Laser Scanning Microscope | Provides images in the highest resolutions in all dimensions. |
| Jasco J-815 CD Spectrophotometer | Circular dichroism (CD) spectroscopy explores the structure and stability of small and biological chiral molecules. |
Additional information
| Title | Hyperlink |
|---|---|
| Faculty of Science launches bioanalytical core facility for research community (YSciCore) | http://www.yorku.ca/yfile/2018/02/21/faculty-of-science-launches-bioanalytical-core-facility-for-r… |
| Information about YSciCore | http://yscicore.info.yorku.ca/files/2019/09/4PANEL_YSCICORE_dec21.pdf |
| Overview of the YSciCore (video) | http://www.youtube.com/watch?v=aiNMb1u2flU |